What is GW-501516? Does it have any side effects? What effects can you expect when using this measure? What should you know before buying? These and other questions will be answered in the article below.
What is Cardarine?
Sarm GW-501516 capsulesCardarine, also known as GW-501516 or Endurobol, is a substance created in the nineties by two pharmaceutical concerts GlaxoSmithKline and Ligand Pharmaceuticals. Its main goal is to stop diseases related to heart disease and metabolic syndrome. Thanks to its amazing ability to accelerate metabolism and burn fat tissue, it quickly gained popularity among athletes.
Due to its selective action, GW-501516 is often mistakenly classified as SARMs (Selective Androgen Receptor Modulators). In fact, it is an agonist of PPARδ receptors.
Activation of the PPAR-delta pathway causes a sudden increase in endurance and acceleration of metabolism, while reducing the level of blood lipids.
Although GW-501516 is known mainly to athletes as an excellent reduction supplement, it also has a large list of other advantages:
Accelerates fat burning
For many people, the most important feature of Cardarine. The effect of GW-501516, however, differs significantly from the average reduction supplements, which usually contain only thermogenic substances. By affecting the PPAR-delta pathway, it activates a large number of genes responsible for fat burning. It also changes the way our body reacts to meals with a high glycemic index
“Here we report that mRNA expression of PPARδ was increased in the skeletal muscle from exercise responders, which may provide a mechanism for the positive changes in the lipid profile and insulin sensitivity in this group. PPARδ functions as a lipid sensor that coordinates changes in gene expression to promote oxidative metabolism in skeletal muscle . Recent evidence from our laboratory shows PPARδ agonists mimic an exercise response by promoting gene regulatory responses in cultured human skeletal muscle ”
Increases endurance and strength
Increasing endurance is associated with the activation of the PPARδ pathway. It changes the way our body metabolizes fats and glucose, thereby ensuring greater endurance. This is confirmed both by the opinions of people using GW-501516 and clinical trials. In one such study, mice were subjected to heavy endurance training, and after using Cardarine they were able to run a much longer distance than in the control study, while showing an increased tolerance to chronic exercise.