MK-677 by Bayer Labs is a reputable preparation for oral use, the main purpose of which is to increase the concentration of growth hormone and insulin-like growth factor type 1 in the blood. For this reason, it is successfully used in the cycles of athletes, as well as in the therapies of sarcopenia and osteopenia.
MK-677 or Ibutamoren are the most popular names of the agent synthesized over 20 years ago, which can be considered to some extent a derivative of a peptide called GHRP-6. However, unlike its older brother, the MK-677 does not need to be used by the paraenteral route. By using GHS-R receptors, this agent is able to exert numerous effects on tissues throughout the body. Due to its action similar to ghrelin, the agent has two basic tasks – to raise the release of growth hormone (GH) and to fuel the appetite of the person using it.
MK-677 – ORAL GROWTH HORMONE?
One of the most commonly used comparisons for MK-677 is its term “Oral Growth Hormone”. In fact, as a result of the use of MK-677, growth hormone levels increase dramatically. This is due to the intensification of the natural ejection of this compound from the human pituitary gland. This compound, being a ligand for the previously mentioned GHS-R (Growth Hormone Secretagogue Receptor) receptors, stimulates somatotropes in the anterior pituitary gland to produce and secrete somatotropin, ie growth hormone. How effective? Research reports that by using standard doses of MK-677 once a day, the body is able to produce 100 to 120% more growth hormone than before treatment. Importantly, the agent starts working immediately after taking it orally – it does not require injections to show excellent effectiveness. At present, due to the above-mentioned parameters, it remains completely unrivaled.
THE ADVANTAGES OF THE LONG SEMI-LIFE OF IBUTAMOREN
Aside from the convenient oral form, MK-677 remains high and stable in blood levels for up to 24 hours after ingestion. This means that it can be successfully used once a day and still provide the full spectrum of benefits offered.
In addition, the prolonged period of action has one more significant plus – effective increase in IGF-1 concentration. Due to the achievement of many high peaks during the day, the growth hormone remains constantly elevated. This results in a gradual increase in IGF-1, which is the factor commonly believed to be the most potent promoter of cell growth in the body.
POWERFUL SUPPORT IN MASS CONSTRUCTION
Many people find that MK-677 is the absolute best means to build muscle mass for beginners and advanced; there are several reasons for this.
First of all, Ibutamoren stimulates 2 hormones considered to be the most important for the development of muscle mass at the highest level of advancement; growth hormone and IGF-1. Thanks to them, there is a possibility of actual muscle hypertrophy, i.e. cell multiplication. In addition, they are able to stimulate numerous anabolic pathways, which also leads to better regeneration.
Second, MK-677 is one of the most powerful appetite boosters on the market. Thanks to this measure, even a slim person is able to consume 10,000 calories a day without much difficulty. Such high efficiency has led to the extinction of the once extremely popular syrup based on megestrol acetate, which increased the appetite. MK-677 works equally spectacularly, but it brings many fewer side effects.
Third, Ibutamoren greatly promotes the development of muscle strength. It is, in a way, the aftermath of the aforementioned effects; Nevertheless, the fact is that when used even in low doses, it noticeably increases exercise capacity in the first week. This, in turn, allows for even more intense muscle stimulation during training, which directly translates into the recording of greater muscle gains.
The last, especially important for beginners, reason to choose MK-677 as a support for building muscle mass is a mild effect on testosterone. Both in clinical trials and in practice, the agent used in reasonable doses and periods remained indifferent to testosterone levels. Thus, it can be successfully used by people who do not want or cannot afford to take androgens as a base for the cycle.